Article
Rheumatoid-susceptible alleles of HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA.
Annals of the rheumatic diseases - 1 Sept 1994
Toda Y, Minamikawa Y, Akagi S, Sugano H, Mori Y, Nishimura H, Arita S, Sugino Y, Ogawa R
Abstract excerpt
OBJECTIVE: To assess the relationship between HLA-DRB1 genotypes and the progression of bone destruction in Japanese patients with RA. METHODS: The HLA-DRB1 alleles were determined by polymerase chain reaction and allele specific oligonucleotide probe techniques in 160 Japanese patients with RA....
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Arthritis, Rheumatoid
- Cross-Sectional Studies
- Disease Progression
- Female
- Finger Joint
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged