Article
Rheumatoid-susceptible alleles of HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA.
Annals of the rheumatic diseases - 1 Sept 1994
Toda Y, Minamikawa Y, Akagi S, Sugano H, Mori Y, Nishimura H, Arita S, Sugino Y, Ogawa R
Abstract excerpt
OBJECTIVE: To assess the relationship between HLA-DRB1 genotypes and the progression of bone destruction in Japanese patients with RA. METHODS: The HLA-DRB1 alleles were determined by polymerase chain reaction and allele specific oligonucleotide probe techniques in 160 Japanese patients with RA. HLA-DR 0101, 0401, 0404, 0405, 1001 and 1402 were regarded as susceptible alleles of RA according to previous reports....
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