Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma.

American journal of respiratory and critical care medicine - 1 Mar 1999

Satoh N, Asano K, Naoki K, Fukunaga K, Iwata M, Kanazawa M, Yamaguchi K

Abstract excerpt

Platelet-activating factor (PAF), a phospholipid with a wide range of proinflammatory actions, is immediately degraded and inactivated in vivo by PAF acetylhydrolase (PAF-AH). Surprisingly, 4% of the Japanese population lacks the extracellular isoform of this enzyme, plasma PAF-AH, due to a genetic missense (V279F) mutation. We studied the association of this mutation with asthma prevalence and phenotypes in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Alleles

Share to Asthma

Share to Mutation, Missense

Share to Phospholipases A

Source

Identifiers

PMID: 10051281
DOI: 10.1164/ajrccm.159.3.9807093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma.PMID 10051281Read ↗

Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma.Semantic proximity Read ↗

Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.Semantic proximity Read ↗

The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma.Semantic proximity Read ↗

Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma.Semantic proximity Read ↗

Platelet-activating factor acetylhydrolases in health and disease.Semantic proximity Read ↗

PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency.Semantic proximity Read ↗

Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan.Semantic proximity Read ↗

Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population.Semantic proximity Read ↗

A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke.Semantic proximity Read ↗

[Study on the association of platelet-activating factor acetylhydrolase with asthmatic children].Semantic proximity Read ↗

Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy.Semantic proximity Read ↗

Platelet-activating factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.