Article
Factor VII deficiency and the FVII mutation database.
Human mutation - 1 Jan 2001
McVey J H, Boswell E, Mumford A D, Kemball-Cook G, Tuddenham E G
Abstract excerpt
Factor VII (FVII) is a zymogen for a vitamin K-dependent serine protease essential for the initiation of blood coagulation. It is synthesized primarily in the liver and circulates in plasma at a concentration of approximately 0.5 microg/ml (10 nmol/L). The FVII gene (F7) is located on chromosome 13 (13q34), consists of 9 exons, and spans approximately 12kb. It encodes a mature protein of 406 amino acids, which...
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