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Article

Polymorphic changes in the 5' flanking region of factor VII have a combined effect on promoter strength.

Thrombosis and haemostasis - 1 Nov 2002

Kudaravalli Rama, Tidd Theresa, Pinotti Mirko, Ratti Antonia, Santacroce Rosa, Margaglione Maurizio, Dallapiccola Bruno, Bernardi Francesco, Fortina Paolo, Devoto Marcella, Pollak Eleanor S

Abstract excerpt

Polymorphic differences in the 5' flanking region of the gene encoding procoagulant protein Factor VII (FVII) are associated with variations in FVII coagulant activity (FVII:C) and FVII antigen (FVII:Ag) levels. A decanucleotide insert polymorphism (CCTATATCCT) at 323 bp upstream of the start site of translation correlates with a decrease of approximately 20% FVII: C levels per allele containing this insert....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12428091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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