A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.

doi:10.1161/01.atv.11.3.540

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Article

A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.

Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000

Green F, Kelleher C, Wilkes H, Temple A, Meade T, Humphries S

Abstract excerpt

We have identified a genetic polymorphism of factor VII that is strongly associated with plasma factor VII coagulant activity (factor VIIc) in healthy individuals from the United Kingdom. This polymorphism was detected after Msp I digestion of polymerase chain reaction-amplified genomic DNA. In a sample of 284 men, the frequency of the M2 allele (loss of cutting site) is 0.1, and individuals with the M1M2...

Topics

Aged
Antigens
Arginine
Base Sequence
Codon
Deoxyribonuclease HpaII
Deoxyribonucleases, Type II Site-Specific
Factor VII
Female
Gene Frequency
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamine

Humans

Male

Middle Aged

Molecular Sequence Data

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 1709359
DOI: 10.1161/01.atv.11.3.540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1709359-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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