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Article

A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.

Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000

Green F, Kelleher C, Wilkes H, Temple A, Meade T, Humphries S

Abstract excerpt

We have identified a genetic polymorphism of factor VII that is strongly associated with plasma factor VII coagulant activity (factor VIIc) in healthy individuals from the United Kingdom. This polymorphism was detected after Msp I digestion of polymerase chain reaction-amplified genomic DNA. In a sample of 284 men, the frequency of the M2 allele (loss of cutting site) is 0.1, and individuals with the M1M2...

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Identifiers

PMID: 1709359
DOI: 10.1161/01.atv.11.3.540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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