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Article

Genetic modulation of coagulation factor VII plasma levels: contribution of different polymorphisms and gender-related effects.

Thrombosis and haemostasis - 1 Oct 1998

Di Castelnuovo A, D'Orazio A, Amore C, Falanga A, Kluft C, Donati M B, Iacoviello L

Abstract excerpt

We studied the relationships among different polymorphisms of FVII gene in determining FVII levels, in a sample of 335 male and female Italian volunteers. The hypervariable region 4 (HVR4), the promoter decanucleotide insertion (-323 0/10 bp) and the R353Q polymorphisms of FVII gene were evaluated. The association of HVR4 or -323 0/10 bp polymorphism with plasma FVII levels differed between gender (Interaction...

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PMID: 9798976

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