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Article

Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease.

Journal of genetics - 1 Dec 2009

Shanker Jayashree, Perumal Ganapathy, Maitra Arindam, Rao Veena S, Natesha B K, John Shibu, Hebbagodi Sridhar, Kakkar Vijay V

Abstract excerpt

Elevated factor VII (FVII) level is a risk factor for coronary artery disease (CAD). We investigated the role of R353Q polymorphism in the F7 gene in 139 Indian families with CAD, comprising of 222 affected subjects, 105 unaffected subjects and 126 affected sibling pairs. Plasma per cent FVIIc activity (FVII.c activity) differed ignificantly across R353Q genotype (P < 0.0001). Frequency of subjects with RR and QQ...

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PMID: 20086294
DOI: 10.1007/s12041-009-0042-x

Genes

CAD

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