Article
Aberrant mRNA splicing causes sorbitol dehydrogenase deficiency in C57BL/LiA mice.
Genomics - 15 Nov 1997
Lee F K, Chung S K, Chung S S
Abstract excerpt
Sorbitol dehydrogenase (Sord) catalyzes the interconversion of sorbitol and fructose and is functionally important both in the metabolism of dietary sorbitol and as a source of fructose in semen. Together with aldose reductase, Sord forms the polyol pathway, which plays an important role in the e...
Topics
- Alleles
- Animals
- Cloning, Molecular
- DNA Mutational Analysis
- Genes
- L-Iditol 2-Dehydrogenase
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Organ Specificity
- Point Mutation
- RNA Splicing
- RNA, Messenger