Article
Acadl-SNP based genotyping assay for long-chain acyl-CoA dehydrogenase deficient mice.
Molecular genetics and metabolism - 1 May 2012
Luther Rita J, Almodovar Alvin J O, Fullerton Russell, Wood Philip A
Abstract excerpt
The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders. The insertion vector-based gene targeting strategy used to generate this model has made it difficult to distinguish homozygous and heterozygous genotypes containing targeted Acadl alleles in...
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