CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis.

doi:10.1111/j.1399-0039.1998.tb02993.x

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Article

CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis.

Tissue antigens - 1 May 1998

Braun J, Donner H, Siegmund T, Walfish P G, Usadel K H, Badenhoop K

Abstract excerpt

Graves' disease (GD) and Hashimoto's thyroiditis (HT) are T-cell mediated organ-specific autoimmune disorders with a genetic predisposition. The cytotoxic T-lymphocyte antigen 4 (CTLA-4) molecule is the predominant receptor for B7 on activated T cells and represents a negative regulator for T-cel...

Topics

Abatacept
Antigens, CD
Antigens, Differentiation
CTLA-4 Antigen
Cytosine
Genetic Variation
Graves Disease
Heterozygote
Homozygote
Humans
Immunoconjugates
Promoter Regions, Genetic
Thymine
Thyroiditis, Autoimmune

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