Article
Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2002
Tomoyose Takeaki, Komiya Ichiro, Takara Masaki, Yabiku Kouichi, Kinjo Yoshino, Shimajiri Yoshinori, Yogi Hiroyuki, Kouki Tsuyoshi, Masuda Masato, Takasu Nobuyuki
Abstract excerpt
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) decreases the immune response of T cells by inactivating the signal that occurs with interaction between CD28 on T cells and B7 on antigen-presenting cells. Gene polymorphisms involving CTLA-4 promoter (-318 C/T), exon 1 (49 A/G), and exon 4 (microsatellite (AT)n) have been linked to Hashimoto's thyroiditis (HT) and other autoimmune diseases. HT also has a reported...
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