Article
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.
Molecular biology of the cell - 1 Dec 1997
Pujades C, Alon R, Yauch R L, Masumoto A, Burkly L C, Chen C, Springer T A, Lobb R R, Hemler M E
Abstract excerpt
It was previously shown that mutations of integrin alpha4 chain sites, within putative EF-hand-type divalent cation-binding domains, each caused a marked reduction in alpha4beta1-dependent cell adhesion. Some reports have suggested that alpha-chain "EF-hand" sites may interact directly with ligands. However, we show here that mutations of three different alpha4 "EF-hand" sites each had no effect on binding of...
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