Article
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.
Molecular biology of the cell - 1 Dec 1997
Pujades C, Alon R, Yauch R L, Masumoto A, Burkly L C, Chen C, Springer T A, Lobb R R, Hemler M E
Abstract excerpt
It was previously shown that mutations of integrin alpha4 chain sites, within putative EF-hand-type divalent cation-binding domains, each caused a marked reduction in alpha4beta1-dependent cell adhesion. Some reports have suggested that alpha-chain "EF-hand" sites may interact directly with ligan...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Antigens, CD
- Binding Sites
- Cations, Divalent
- Cell Adhesion
- EF Hand Motifs
- Fibronectins
- Humans
- Immunoglobulin G
- Integrin alpha4
- Integrin alpha4beta1
- Integrins
- K562 Cells