Article
The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3.
Molecular microbiology - 1 Apr 1996
Mahé Y, Parle-McDermott A, Nourani A, Delahodde A, Lamprecht A, Kuchler K
Abstract excerpt
Pleiotropic drug resistance (PDR) in the yeast Saccharomyces cerevisiae can arise from overexpression of ATP-binding cassette (ABC) efflux pumps such as Pdr5 and Snq2. Mutations in the transcription factor genes PDR1 and PDR3 are also associated with PDR. We show here that a pdr1-3 mutant exhibit...
Topics
- 4-Nitroquinoline-1-oxide
- ATP-Binding Cassette Transporters
- Antifungal Agents
- Binding Sites
- Cycloheximide
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Fungal Proteins
- Glycoproteins
- Membrane Proteins
- Mutagens
- Mutation
- Promoter Regions, Genetic