Article
The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
Cell - 5 Apr 1991
Surana U, Robitsch H, Price C, Schuster T, Fitch I, Futcher A B, Nasmyth K
Abstract excerpt
cdc28-1N is a conditional allele that has normal G1 (Start) function but confers a mitotic defect. We have isolated seven genes that in high dosage suppress the growth defect of cdc28-1N cells but not of Start-defective cdc28-4 cells. Three of these (CLB1, CLB2, and CLB4) encode proteins strongly homologous to G2-specific B-type cyclins. Another gene, CLB3, was cloned using PCR, CLB1 and CLB2 encode a pair of...
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