Article
Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation.
Mechanisms of development - 1 Oct 1997
Leenders W P, van Genesen S T, Schoenmakers J G, van Zoelen E J, Lubsen N H
Abstract excerpt
Fibroblast growth factors (FGFs) are the only known factors that can induce differentiation of the mammalian lens epithelial cell, while insulin acts only as a mitogen, not as a morphogen. We show here that insulin enhances expression of the alphaA-crystallin gene in lens epithelial cells and induces the synthesis of lens fibre cell specific betaB2- and gamma-crystallins in early differentiated fibre cells....
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