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Article

Effect of Growth Factors on the Proliferation and Gene Expression of Human Meibomian Gland Epithelial Cells

15 Mar 2013

Abstract excerpt

PURPOSE: We hypothesize that growth factors, including epidermal growth factor (EGF) and bovine pituitary extract (BPE), induce proliferation, but not differentiation (e.g., lipid accumulation), of human meibomian gland epithelial cells. We also hypothesize that these actions involve a significant upregulation of genes linked to cell cycle processes, and a significant downregulation of genes associated with...

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PMID: 23493293
DOI: 10.1167/iovs.12-11221

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