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Article

Transcriptional Regulation of Insulin-like Growth Factor-I by Interferon-γ Requires STAT-5b

1 Jan 2004

Abstract excerpt

Insulin-like growth factor (IGF)-I, a growth factor important for cell proliferation, cellular differentiation, and multiple metabolic functions, is regulated in vivo by growth factors and cytokines, but the mechanism(s) of regulation at the cellular level is not well understood. We now demonstrate, employing primary human dermal fibroblasts (CF), that the multipotent cytokine, interferon-gamma (IFN-gamma), can...

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PMID: 14570891
DOI: 10.1074/jbc.m310495200

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