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Article

FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.

BMC cancer - 27 Sept 2010

Chang Patrick, Kang Michelle, Xiao Anny, Chang Jeffrey, Feusner James, Buffler Patricia, Wiemels Joseph

Abstract excerpt

BACKGROUND: Mutations in FLT3 result in activated tyrosine kinase activity, cell growth stimulation, and a poor prognosis among various subtypes of leukemia. The causes and timing of the mutations are not currently known. We evaluated the prevalence and timing of origin of FLT3 mutations in a pop...

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Source

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Identifiers

PMID: 20875128
DOI: 10.1186/1471-2407-10-513
PMCID: PMC2955609

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20875128-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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