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Article

Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2003

Horwitz Gregory A, Miklovsky Irina, Heaney Anthony P, Ren Song-Guang, Melmed Shlomo

Abstract excerpt

Pituitary tumor-transforming gene (PTTG) originally isolated from GH-secreting pituitary adenoma cells causes in vitro cell transformation, in vivo tumorigenesis, and induces basic fibroblast growth factor. These functions require an intact C-terminal proline-proline-serine-proline motif. PTTG1 is abundantly expressed in human pituitary tumors and plays a role in the early stages of experimental prolactinoma...

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Source

Identifiers

PMID: 12554778
DOI: 10.1210/me.2001-0006

Genes

PTTG1
PRL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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