Article
[The role of p53 gene during the development of human oral malignant lesions: a comparative study of p53 gene mutation with P53 protein positive immunostaining].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao - 1 Sept 1996
Chen Q, Yang G, Fu J, Li B
Abstract excerpt
In order to increase the sensitivity to immunostaining in formalinfixed, paraffin-embedded tissues, we developed an immunohistochemical method by microwave heating of tissue sections instead of trypsin digestion. The results of this study showed that there was no positive P53 protein reaction in...
Topics
- Carcinoma, Squamous Cell
- Gene Expression
- Genes, p53
- Humans
- Lymphatic Metastasis
- Mouth Neoplasms
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precancerous Conditions
- Tumor Suppressor Protein p53