Article
Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies.
Cytokines and molecular therapy - 1 Dec 1996
Demeter J, Messer G, Rämisch S, Mee J B, di Giovine F S, Schmid M, Herrmann F, Porzsolt F
Abstract excerpt
Alleles of the IL-1 genes are associated with several autoimmune and inflammatory diseases, where they tend to have a role in the severity of the disease rather than in susceptibility to the disease itself. Allele 2 of the variable number tandem repeat (VNTR) polymorphism in the IL-1 receptor antagonist (IL-1ra) gene was the first marker of the IL-1 cluster to be associated in this way with severity of chronic,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.