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Article

Allele 2 of the interleukin-1 receptor antagonist gene (IL1RN*2) is associated with a decreased risk of primary lung cancer.

Cancer letters - 18 May 2006

Hu Zhibin, Shao Minhua, Chen Yijiang, Zhou Jiannong, Qian Ji, Xu Lin, Ma Hongxia, Wang Xinru, Xu Yaochu, Lu Daru, Shen Hongbing

Abstract excerpt

IL-1 receptor antagonist (IL-1ra), a structural variant of IL-1, binds to the same IL-1 receptor and acts as a competitive inhibitor of IL-1 bioactivity. IL-1ra protein has been widely investigated and found to be associated with different human malignancies. In the second intron of the IL-1RN gene, there is a functional polymorphism of a variable number of tandem repeats (VNTR), which is characterized as having...

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Identifiers

PMID: 16019127
DOI: 10.1016/j.canlet.2005.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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