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Article

A Novel Antioxidant Gene from <i>Mycobacterium tuberculosis </i>

1 Dec 1997

Abstract excerpt

Among the major antimicrobial products of macrophages are reactive intermediates of the oxidation of nitrogen (RNI) and the reduction of oxygen (ROI). Selection of recombinants in acidified nitrite led to the cloning of a novel gene, noxR1, from a pathogenic clinical isolate of Mycobacterium tuberculosis. Expression of noxR1 conferred upon Escherichia coli and Mycobacterium smegmatis enhanced ability to resist...

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PMID: 9382887
DOI: 10.1084/jem.186.11.1885

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