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Article

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.

Annals of neurology - 1 Oct 1997

Beal M F, Ferrante R J, Browne S E, Matthews R T, Kowall N W, Brown R H

Abstract excerpt

The pathogenesis of neuronal degeneration in both sporadic and familial amyotrophic lateral sclerosis (ALS) associated with mutations in superoxide dismutase may involve oxidative stress. A leading candidate as a mediator of oxidative stress is peroxynitrite, which is formed by the reaction of superoxide with nitric oxide. 3-Nitrotyrosine is a relatively specific marker for oxidative damage mediated by...

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PMID: 9382477
DOI: 10.1002/ana.410420416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.PMID 9382477Read ↗

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.Semantic proximity Read ↗

Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.Semantic proximity Read ↗

Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.Semantic proximity Read ↗

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

S-nitrosothiol depletion in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Manganese superoxide dismutase levels are elevated in a proportion of amyotrophic lateral sclerosis patient cell lines.Semantic proximity Read ↗

Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis.Semantic proximity Read ↗

Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Degeneration of NO-synthesizing cerebrocortical neurons in transgenic mice expressing mutated superoxide dismutase is not due to elevated nitric oxide levels.Semantic proximity Read ↗

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