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Article

Manganese superoxide dismutase levels are elevated in a proportion of amyotrophic lateral sclerosis patient cell lines.

Biochemical and biophysical research communications - 24 Jun 2000

McEachern G, Kassovska-Bratinova S, Raha S, Tarnopolsky M A, Turnbull J, Bourgeois J, Robinson B

Abstract excerpt

The most frequent genetic causes of amyotrophic lateral sclerosis (ALS) determined so far are mutations occurring in the gene for copper/zinc superoxide dismutase (CuZnSOD). The mechanism may involve inappropriate formation of hyroxyl radicals, peroxynitrite or malfunctioning of the SOD protein. We hypothesized that undiscovered genetic causes of sporadically occurring amyotrophic lateral sclerosis might be found...

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Identifiers

PMID: 10873611
DOI: 10.1006/bbrc.2000.2933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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