Article
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.
Journal of neurochemistry - 1 Dec 1993
Bowling A C, Schulz J B, Brown R H, Beal M F
Abstract excerpt
The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is unknown. Recently, it was found that some patients with autosomal-dominant familial ALS (FALS) have point mutations in the gene that encodes Cu/Zn superoxide dismutase (SOD1). In this study of postmortem brain tissue, we examin...
Topics
- Adult
- Amyotrophic Lateral Sclerosis
- Autopsy
- Brain
- Citrate (si)-Synthase
- Electron Transport
- Energy Metabolism
- Family
- Female
- Genes, Dominant
- Humans
- Male
- Middle Aged
- Mitochondria
- Mutation
- Oxidative Phosphorylation
- Reference Values
- Superoxide Dismutase