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Article

Reprogramming Substrate and Catalytic Promiscuity of Tryptophan Prenyltransferases.

Journal of molecular biology - 22 Jan 2021

Ostertag Elena, Zheng Liujuan, Broger Karina, Stehle Thilo, Li Shu-Ming, Zocher Georg

Abstract excerpt

Prenylation is a process widely prevalent in primary and secondary metabolism, contributing to functionality and chemical diversity in natural systems. Due to their high regio- and chemoselectivities, prenyltransferases are also valuable tools for creation of new compounds by chemoenzymatic synthesis and synthetic biology. Over the last ten years, biochemical and structural investigations shed light on the...

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Identifiers

PMID: 33249189
DOI: 10.1016/j.jmb.2020.11.025

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