Article
A small molecule agonist of an integrin, alphaLbeta2.
The Journal of biological chemistry - 8 Dec 2006
Yang Wei, Carman Christopher V, Kim Minsoo, Salas Azucena, Shimaoka Motomu, Springer Timothy A
Abstract excerpt
The binding of integrin alpha(L)beta(2) to its ligand intercellular adhesion molecule-1 is required for immune responses and leukocyte trafficking. Small molecule antagonists of alpha(L)beta(2) are under intense investigation as potential anti-inflammatory drugs. We describe for the first time a small molecule integrin agonist. A previously described alpha/beta I allosteric inhibitor, compound 4, functions as an...
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