Article
Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.
The Journal of biological chemistry - 13 Dec 2013
Brandis Katrina A, Gale Sarah, Jinn Sarah, Langmade Stephen J, Dudley-Rucker Nicole, Jiang Hui, Sidhu Rohini, Ren Aileen, Goldberg Anna, Schaffer Jean E, Ory Daniel S
Abstract excerpt
Mobilization of plasma membrane (PM) cholesterol to the endoplasmic reticulum is essential for cellular cholesterol homeostasis. The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understood. Because mutant cells with defects in PM to endoplasmic reticulum cholesterol trafficking can be isolated on the basis of resistance to amphotericin B, we conducted an amphotericin B...
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