Article
Genotypic selection methods for the direct analysis of point mutations.
Mutation research - 1 Oct 1997
Parsons B L, Heflich R H
Abstract excerpt
Genotypic selection enriches a particular DNA sequence relative to another closely-related DNA sequence based only on a change of one or a few bases. This review is a survey of the genotypic selection methods that have the sensitivity to detect rare point mutations. These methods are primarily being used to study mutations caused by environmental mutagens; however, the ability to detect and measure very minor DNA...
Topics
- Animals
- DNA Mutational Analysis
- Genotype
- Humans
- Point Mutation
- Polymerase Chain Reaction