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Article

Cloning and characterization of a dominant-negative vps1 allele of the yeast Saccharomyces cerevisiae.

Biological chemistry - 1 Oct 1997

Finken-Eigen M, Müller S, Köhrer K

Abstract excerpt

The gene product of the yeast VPS1 gene is a member of a family of high-molecular-weight GTP-binding proteins that are involved in diverse cellular processes. The Vps1 protein (Vps1p) was shown to perform an essential function in the yeast secretory pathway. Here, we report the isolation and characterization of a mutant allele of the VPS1 gene, causing a dominant-negative vacuolar protein sorting (vps) defect, as...

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PMID: 9372190

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