Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect

1 Dec 1994

Abstract excerpt

While the majority of metazoan genes and those of the DNA viruses which infect them contain introns which require RNA splicing, herpes simplex virus type 1 (HSV-1) encodes relatively few spliced products. We previously showed that the HSV-1 immediate-early protein ICP27 decreased the levels of spliced target mRNAs in transfections and spliced cellular mRNAs during infection, suggesting that ICP27 may function in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7966568
DOI: 10.1128/jvi.68.12.7790-7799.1994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effectPMID 7966568Read ↗

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infectionSemantic proximity Read ↗

Herpes simplex virus ICP27 regulates alternative pre-mRNA polyadenylation and splicing in a sequence-dependent mannerSemantic proximity Read ↗

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.Semantic proximity Read ↗

Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27Semantic proximity Read ↗

The many roles of the regulatory protein ICP27 during herpes simplex virus infectionSemantic proximity Read ↗

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expressionSemantic proximity Read ↗

The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicingSemantic proximity Read ↗

Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Semantic proximity Read ↗

Splicing Inhibition at the Level of Spliceosome Assembly in the Presence of Herpes Simplex Virus Protein ICP27Semantic proximity Read ↗

Processing of alpha-globin and ICP0 mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants.Semantic proximity Read ↗

Role of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAsSemantic proximity Read ↗

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.