Article
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.
European journal of biochemistry - 15 Nov 1993
Kelly J M, Taylor M C, Smith K, Hunter K J, Fairlamb A H
Abstract excerpt
Trypanothione reductase is thought to be important in maintaining an intracellular reducing environment in trypanosomatids. To investigate the role of trypanothione reductase we transfected Leishmania donovani and Trypanosoma cruzi with an expression vector containing the L. donovani trypanothion...
Topics
- Animals
- Base Sequence
- DNA Primers
- Genes, Protozoan
- Gentian Violet
- Hydrogen Peroxide
- Leishmania donovani
- Microbial Sensitivity Tests
- Molecular Sequence Data
- NADH, NADPH Oxidoreductases
- Nitrofurans
- Oxidation-Reduction
- Phenotype
- Recombinant Proteins