Article
Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole.
Molecular and biochemical parasitology - 30 Oct 1998
Temperton N J, Wilkinson S R, Meyer D J, Kelly J M
Abstract excerpt
The parasitic protozoan Trypanosoma cruzi is exposed to toxic oxygen metabolites which arise from drug metabolism or immune mechanisms, in addition to those produced by endogenous processes. Identification and functional analysis of parasite enzymes which confer protection against oxidative stres...
Topics
- Animals
- Dose-Response Relationship, Drug
- Gene Expression
- Genes, Protozoan
- Gentian Violet
- Nitroimidazoles
- Phenotype
- Superoxide Dismutase
- Transformation, Genetic
- Trypanocidal Agents
- Trypanosoma cruzi