The molecular basis of virulence of the encephalitogenic flaviviruses.

Abstract excerpt

Summary: Studies of flavivirus virulence have focussed on variants with differing neurovirulence or neuroinvasiveness in animal models, with the majority based on determining the contribution of viral structural proteins, in particular the envelope glycoprotein. Specific virulence determinants on protein E have recently been identified by the application of several experimental techniques such as selection and...

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