Article
Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.
The Journal of clinical investigation - 15 Nov 1997
Rybalkin S D, Bornfeldt K E, Sonnenburg W K, Rybalkina I G, Kwak K S, Hanson K, Krebs E G, Beavo J A
Abstract excerpt
The diversity among cyclic nucleotide phosphodiesterases provides multiple mechanisms for regulation of cAMP and cGMP in the cardiovascular system. Here we report that a calmodulin-stimulated phosphodiesterase (PDE1C) is highly expressed in proliferating human arterial smooth muscle cells (SMCs) in primary culture, but not in the quiescent SMCs of intact human aorta. High levels of PDE1C were found in primary...
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