Article
Isoniazid-induced hepatic necrosis and steatosis in rabbits: absence of effect of gender.
Canadian journal of physiology and pharmacology - 1 Sept 1997
Sarich T C, Adams S P, Zhou T, Wright J M
Abstract excerpt
Isoniazid, a highly effective drug for the chemoprophylaxis and treatment of tuberculosis, is associated with severe hepatotoxicity in 1-2% of individuals. In a rabbit model of isoniazid-induced hepatotoxicity, we have measured hepatic necrosis (quantitated by elevation of plasma argininosuccinic...
Topics
- Animals
- Antitubercular Agents
- Argininosuccinate Lyase
- Fatty Liver
- Female
- Hypertriglyceridemia
- Isoniazid
- Liver
- Male
- Necrosis
- Phenotype
- Rabbits
- Sex Factors
- Sulfamethazine
- Triglycerides