Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoniazid-induced hepatic necrosis and steatosis in rabbits: absence of effect of gender.

Canadian journal of physiology and pharmacology - 1 Sept 1997

Sarich T C, Adams S P, Zhou T, Wright J M

Abstract excerpt

Isoniazid, a highly effective drug for the chemoprophylaxis and treatment of tuberculosis, is associated with severe hepatotoxicity in 1-2% of individuals. In a rabbit model of isoniazid-induced hepatotoxicity, we have measured hepatic necrosis (quantitated by elevation of plasma argininosuccinic acid lyase (ASAL) activity), hepatic steatosis (quantitated by elevation of hepatic triglyceride content), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Hypertriglyceridemia
Share to Isoniazid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Rabbits

Share to Sex Factors

Share to Triglycerides

Source

Identifiers

PMID: 9365821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Isoniazid-induced hepatic necrosis and steatosis in rabbits: absence of effect of gender.PMID 9365821Read ↗

Case Report: Acute isoniazid intoxication after intentional ingestionSemantic proximity Read ↗

Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation.Semantic proximity Read ↗

Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype.Semantic proximity Read ↗

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group.Semantic proximity Read ↗

NAT2 Slow Acetylator Phenotype as a Significant Risk Factor for Hepatotoxicity Caused by Antituberculosis Drugs: Results From a Multiethnic Nested Case-Control Study.Semantic proximity Read ↗

Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity.Semantic proximity Read ↗

Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and ManagementSemantic proximity Read ↗

Association between TXNRD1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a prospective study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.