Neonatal and adult O4⁺ oligodendrocyte lineage cells display different growth factor responses and different gene expression patterns

Abstract excerpt

Oligodendrocytes are the myelinating cells of the central nervous system. Although the CNS possesses the ability to repair demyelinating insults, in certain cases, such as the chronic lesions found in multiple sclerosis, remyelination fails. Cycling cells capable of becoming oligodendrocytes have been identified in both the developing and the adult mammalian forebrain. Many studies have focused on differences in...