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Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung

1 Dec 1997

Abstract excerpt

Lung carcinoids occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). There are no well defined genetic abnormalities known to occur in these tumors. We studied 11 sporadic lung carcinoids for loss of heterozygosity (LOH) at the locus of the MEN1 gene on chromosome 11q13, and for mutations of the MEN1 gene using dideoxy fingerprinting. Additionally, a lung carcinoid from a...

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PMID: 9361035
DOI: 10.1093/hmg/6.13.2285

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