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Long Polyglutamine Tracts in the Androgen Receptor Are Associated with Reduced<i>Trans</i>-Activation, Impaired Sperm Production, and Male Infertility<sup>1</sup>

1 Nov 1997

Abstract excerpt

The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that code for polyglutamine and polyglycine tracts in the N-terminal trans-activation domain of the AR protein. Changes in the lengths of these polymorphic repeat segments have been associated with increased risk of prostate cancer, an androgen-dependent tumor. Expansion of the polyglutamine tract causes a rare...

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PMID: 9360540
DOI: 10.1210/jcem.82.11.4385

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Long Polyglutamine Tracts in the Androgen Receptor Are Associated with Reduced<i>Trans</i>-Activation, Impaired Sperm Production, and Male Infertility<sup>1</sup>PMID 9360540Read ↗

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