Article
Immune system genes in multiple sclerosis: genetic association and linkage analyses on TCR beta, IGH, IFN-gamma and IL-1ra/IL-1 beta loci.
Journal of neuroimmunology - 1 Oct 1997
Wansen K, Pastinen T, Kuokkanen S, Wikström J, Palo J, Peltonen L, Tienari P J
Abstract excerpt
The role of genetic factors in the etiology of multiple sclerosis (MS) has been clearly demonstrated but the loci determining susceptibility to this disease remain largely unidentified. A contribution from several immune system genes has been suggested based on animal models and association/linka...
Topics
- Adult
- Aged
- Aged, 80 and over
- Chromosome Mapping
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Immune System
- Immunoglobulin Heavy Chains
- Interferon-gamma
- Interleukin-1
- Male
- Middle Aged
- Multiple Sclerosis
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Interleukin-1