Article
Structure of the cyclin-dependent kinase inhibitor p19Ink4d.
Nature - 30 Oct 1997
Luh F Y, Archer S J, Domaille P J, Smith B O, Owen D, Brotherton D H, Raine A R, Xu X, Brizuela L, Brenner S L, Laue E D
Abstract excerpt
In cancer, the biochemical pathways that are dominated by the two tumour-suppressor proteins, p53 and Rb, are the most frequently disrupted. Cyclin D-dependent kinases phosphorylate Rb to control its activity and they are, in turn, specifically inhibited by the Ink4 family of cyclin-dependent kinase inhibitors (CDKIs) which cause arrest at the G1 phase of the cell cycle. Mutations in Rb, cyclin D1, its catalytic...
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