Article
Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.
Calcified tissue international - 1 Nov 1997
Varga F, Rumpler M, Luegmayr E, Fratzl-Zelman N, Glantschnig H, Klaushofer K
Abstract excerpt
Thyroid hormones influence growth and differentiation of bone cells. In vivo and in vitro data indicate their importance for development and maintenance of the skeleton. Triiodothyronine (T3) inhibits proliferation and accelerates differentiation of osteoblasts. We studied the regulatory effect o...
Topics
- 3T3 Cells
- Alkaline Phosphatase
- Animals
- Cell Differentiation
- Dose-Response Relationship, Drug
- Down-Regulation
- Gene Expression Regulation
- Genes, fos
- Genes, jun
- Histones
- Mice
- Osteoblasts
- Osteocalcin
- Phenotype
- RNA, Messenger
- Triiodothyronine