Mutations in the Gene Encoding for the <i>β</i> 2-adrenergic Receptor in Normal and Asthmatic Subjects

Abstract excerpt

Abstract It has long been hypothesized that a defective β2-adrenergic receptor (β2AR) may be a pathogenic factor in bronchial asthma. We examined the gene encoding the β2AR to assess the frequency of polymorphisms in 51 patients with moderate to severe asthma and 56 normal subjects. Nine different point mutations were found in both heterozygous and homozygous forms at nucleic acid residues 46, 79, 100, 252, 491,...

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