Article
Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae.
Molecular microbiology - 1 Sept 1997
Carroll P A, Tashima K T, Rogers M B, DiRita V J, Calderwood S B
Abstract excerpt
We evaluated a spontaneous mutant of Vibrio cholerae, which was avirulent in an infant mouse and had reduced expression of cholera toxin and TcpA in response to environmental signals. The toxR, toxS and toxT genes in the mutant were normal, but transcription of toxT was absent. A plasmid expressing wild-type tcpP and tcpH complemented the mutant. The mutation resulted from a frameshift in a string of nine G...
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