Article
Flexibility of Vibrio cholerae ToxT in transcription activation of genes having altered promoter spacing.
Journal of bacteriology - 1 Dec 2008
Bellair Michelle, Withey Jeffrey H
Abstract excerpt
Cholera, a severe diarrheal disease, is caused by ingestion of the gram-negative bacterium Vibrio cholerae. Expression of V. cholerae virulence factors is highly regulated at the transcriptional and posttranscriptional levels by a complex network of proteins and small noncoding RNAs. The direct activator of transcription of most V. cholerae virulence genes is the ToxT protein. ToxT binds to a 13-bp sequence, the...
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