Article
Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts.
The Journal of biological chemistry - 31 Oct 1997
Ford J M, Hanawalt P C
Abstract excerpt
We have shown previously that Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in the removal of UV-induced cyclobutane pyrimidine dimers from genomic DNA, but still proficient in the transcription-coupled repair pathway (Ford, J. M., and Hanawalt, P. C. (1995) Proc. Na...
Topics
- Cells, Cultured
- DNA Repair
- Fibroblasts
- Gene Expression
- Genome, Human
- Homozygote
- Humans
- Mutation
- Tumor Suppressor Protein p53
- Ultraviolet Rays