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Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers

10 Sept 2010

Abstract excerpt

For repair of damaged DNA, cells increase de novo synthesis of deoxyribonucleotide triphosphates through the rate-limiting, p53-regulated ribonucleotide reductase (RNR) enzyme. In this study we investigated whether pharmacological inhibition of RNR by 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) enhanced chemoradiation sensitivity through a mechanism involving sustained DNA damage. RNR...

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PMID: 20954859
DOI: 10.1667/rr2273.1

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