Article
DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model.
Gene therapy - 1 Oct 2014
Weng T-Y, Yen M-C, Huang C-T, Hung J-J, Chen Y-L, Chen W-C, Wang C-Y, Chang J-Y, Lai M-D
Abstract excerpt
Mutant Kras (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is observed in more than 20% of non-small-cell lung cancers; however, no effective Kras target therapy is available at present. The Kras DNA vaccine may represent as a novel immunotherapeutic agent in lung cancer. In this study, we investigated the antitumor efficacy of the Kras DNA vaccine in a genetically engineered inducible mouse lung tumor...
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