Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.

Biochemical and biophysical research communications - 9 Oct 1997

Klöting I, Kovacs P, Kuttler B

Abstract excerpt

Besides other factors, lymphopenia (ll) is essential for development of insulin-dependent diabetes mellitus in the BB rat. It is unknown which phenotypic consequence may have a non-lymphopenia. Therefore, the region containing the lymphopenia gene of the BB/OK rat was replaced with that of the non-lymphopenic (LL) and hypertensive rat, SHR (11 cM, D4Mit6-LL-Npy-Spr). The resulting congenic strain, BB.LL, did not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Body Weight
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipids

Share to Motor Activity

Share to Phenotype

Share to Rats, Inbred SHR

Source

Identifiers

PMID: 9345278
DOI: 10.1006/bbrc.1997.7436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.PMID 9345278Read ↗

The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes.Semantic proximity Read ↗

Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

Congenic mapping of type 1 diabetes--protective gene(s) in an interval of 4 Mb on rat chromosome 6q32.Semantic proximity Read ↗

Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.Semantic proximity Read ↗

Phenotypic and genetic analyses of subcongenic BB.SHR rat lines shorten the region on chromosome 4 bearing gene(s) for underlying facets of metabolic syndrome.Semantic proximity Read ↗

Sequence variation and expression of the Gimap gene family in the BB rat.Semantic proximity Read ↗

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.Semantic proximity Read ↗

Coat colour phenotype, leucopenia, and insulin-dependent diabetes mellitus (IDDM) in BB rats.Semantic proximity Read ↗

Incidence and phenotype restriction of lymphoid BLT-serine protease granules in spontaneously diabetes prone BB rats compared with a normal rat strain.Semantic proximity Read ↗

Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.Semantic proximity Read ↗

Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.